ARGININE DEPRIVATION INHIBITS THE WARBURG EFFECT AND UPREGULATES GLUTAMINE ANAPLEROSIS AND SERINE BIOSYNTHESIS IN ASS1-DEFICIENT CANCERS

Arginine Deprivation Inhibits the Warburg Effect and Upregulates Glutamine Anaplerosis and Serine Biosynthesis in ASS1-Deficient Cancers

Targeting defects in metabolism is an underutilized strategy for the treatment of cancer.Arginine auxotrophy resulting from the silencing of argininosuccinate synthetase 1 (ASS1) is a common metabolic alteration Stacking Tumblers reported in a broad range of aggressive cancers.To assess the metabolic effects that arise from acute and chronic argini

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Developing acceptable contraceptive methods: Mixed-method findings on preferred method characteristics from Burkina Faso and Uganda [version 2; peer review: 2 approved]

Background: Unmet need remains high in developing regions.New contraceptive WASH BRUSH technologies may improve uptake and use.This study examines desirable product characteristics.Methods: We added a module to the female questionnaire of the PMA2020 surveys in Burkina Faso and Uganda and conducted 50 focus group discussions (FGDs) with women, 10 F

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